نتایج جستجو برای: Extrusion-spheronization Pellet

تعداد نتایج: 20963  

Journal: :Chemical & pharmaceutical bulletin 2001
O M Koo P W Heng

In this study, five microcrystalline cellulose (MCC) grades were physically characterized and their extrusion-spheronization behaviours were characterized in terms of water requirements and pellet shape profiles. It was found that the MCC grades differed significantly in the physical properties investigated. Physical properties of MCC were found to influence the water requirement for extrusion-...

Journal: :iranian journal of basic medical sciences 0
hadi afrasiabi garekani pharmaceutical research center, mashhad university of medical sciences, mashhad, iran department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran roshanak dolatabadi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran abbas akhgari targeted drug delivery research center, mashhad university of medical sciences, mashhad, iran department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran mohammad reza abbaspour targeted drug delivery research center, mashhad university of medical sciences, mashhad, iran

objective(s): this study evaluates the effect of substitution of microcrystalline cellulose (mcc) with ethylcellulose (ec) on mechanical and release characteristics of theophylline pellets. materials and methods: the effect of addition of ec was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. also the effect of type of granulating liqui...

2015
Navjot Kanwar Rakesh Kumar

Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches. Various pellet properties were evaluated like size & shape analysis, flow properties, bulk & tapped density, friabilit...

2013
Ketkee Deshmukh Purnima Amin

In the current research work an attempt was made to develop "Melt in mouth pellets" (Meltlets(®)) containing 40% herbal extract of soy isoflavones that served to provide antioxidants activity in menopausal women. The process of extrusion-spheronization was optimized for extruder speed, extruder screen size, spheronization speed, and time. While doing so the herbal extract incorporated in the pe...

The drug making resreach has accentuated on extrusion technology for a long time. The advance of drug bioavailibility, bead manufacturing and granulation is assured by extrusion procedures. There are also diverse effects in resereches with respect to the use of process understanging as a tool in quality management. Many initiatives of FDA such as PAT and QBD are getting accepted. In this survey...

Journal: :Drug development and industrial pharmacy 2014
Sin Yee Puah Hsiu Ni Yap Cheng Shu Chaw

PURPOSE The study looked into the feasibility of producing pellet using Avicel CL611 as spheronization aid by the extrusion/spheronization technique. METHODS Pellets were formulated to contain either 20% or 40% Avicel CL611 and lactose monohydrate as the other sole ingredient. Water is used as liquid binder. Quality of pellets and extrudates were analyzed for size distribution, shape, surface...

2013
S. Ramu G. Ramakrishna M. Balaji K. Kondala rao S. Haranadh reddy D. pavan kumar

The present study aims at discussing the potential advantages of multiple unit dosage forms (pellets etc.) over the single unit dosage forms (tablets). Pelletization is a novel drug delivery system; a technique which converts fine powder particles into pellets. Review deals with the pellet and its various types of pelletization techniques like spheronization and extrusion, pelletization by laye...

2011
A. Akhgari M R. Abbaspour S. Pirmoradi

BACKGROUND AND THE PURPOSE OF THE STUDY Extrusion-spheronization is an established technique for the production of pellets for pharmaceutical applications. In this study, the feasibility and influence of the incorporation of acacia, by itself and in combination with tragacanth, on the ability of formulations containing 2 model of drugs (ibuprofen and theophylline) to form spherical pellets by e...

Journal: :Pakistan journal of pharmaceutical sciences 2014
Sabiha Karim Saringat H Baie Yuen Kah Hay Nadeem Irfan Bukhari

Pelletized dosage forms can be prepared by different methods which, in general, are time consuming and labor intensive. The current study was carried out to investigate the feasibility of preparing the spherical pellets of omeprazole by sieving-spheronization. An optimized formulation was also prepared by extrusion-spheronization process to compare the physical parameters between these two meth...

Journal: :Indian Journal of Pharmaceutical Education and Research 2023

Abstract: Background/Objectives: The objective of the study was to examine feasibility extrusion/ spheronization techniques for formulation castor oil loaded self-emulsifying pellets. also aimed at optimization pellet system with design experiments. Materials and Methods: Various surfactants co-surfactants were tested their ability emulsify oil. proportion components (castor oil, surfactant co-...

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